How to Stop and Reverse Aging

Groups of different aged hands holding each other

Even though the idea of replacing biological parts to recreate “The Curious Case of Benjamin Button” remains science fiction, scientists are already working hard on methods to stop or even reverse aging processes.

Regular blood testing can reveal whether your health habits are contributing to or subtracting from your biological age.

Biotech Approaches

Biotechnology can be an indispensable weapon in the battle against aging. It offers enormous potential: new drugs and regenerative therapies can be developed, vaccines developed, more energy-efficient crops produced, longer lasting materials manufactured and even cleaner environments can all benefit. While its potential is immense, its risks must also be carefully managed if misuse of the technology occurs – creating effective governance mechanisms to set norms and monitor use is vitally important to this field’s future success.

Cellular reprogramming is an exciting field of research. Through this process, scientists convert existing cells to induced pluripotent stem cells (iPSCs). Similar to embryonic stem cells, iPSCs can develop into any cell type in your body and can repair damaged tissues, replace lost cells and rejuvenate aging tissue.

Another approach is using telomeres to slow aging. Telomeres are the caps at the ends of chromosomes that protect them from being permanently damaged and falling apart, and Houston Methodist researchers are developing drugs to extend telomere length for DNA replication and block natural death mechanisms within cells – potentially helping prevent progeria, which causes children to age more quickly than expected their age.

Other biotech approaches to combating aging involve targeting specific diseases. One such approach involves creating gene therapy drugs that re-regulate genes whose activity changes with age; this allows the patient’s immune system to more quickly recognize and eliminate disease-causing pathogens, speeding healing times and decreasing inflammation levels more quickly.

Human mitochondria, the power plants within cells, is another subject of biotech research into anti-aging treatments. A company called Shift Bioscience is working on small molecule drugs that retrain mitochondrial DNA so as to prevent mutations and promote longevity.

Clearing Senescent Cells

Senescent cells aren’t just an indicator of age; they play an active role in chronic disease progression as well. By secreting molecules that trigger inflammation and draining resources needed by younger cells to thrive, senescent cells play a major role in age-related conditions that plague many adults today. Eliminating senescent cells may provide one effective strategy for treating and even reversing many age-related ailments.

Senescence occurs when cells divide an indefinitely limited number of times before eventually ceasing to reproduce and eventually dying off. Cells can become senescent due to various triggers such as DNA damage, oncogene activation or telomere dysfunction; when an accumulation of these senescent cells accumulates within an organ system it can lead to tissue dysfunction and eventually organ failure.

Bill Keyes was working on a mouse model of cellular senescence when he noticed something odd: when staining healthy mouse and chick embryos with beta-galactosidase enzyme, tiny blue spots appeared in certain tissues he suspected may be caused by senescent cells.

Research community took notice, and senescent cells emerged as key players in aging and age-related disease. Studies revealed accumulation of senescent cells in kidney, muscle, liver and fat tissue of older mice; leading to chronic illness and frailty as a result. Scientists began developing drugs to destroy them.

These agents, known as senolytics, have been proven to improve physical function and extend lifespan in mice with naturally aging senescent tissue. As a result, significant research efforts are now being made to find novel compounds which eliminate senescent cells in humans.

Piperlongumine, a small molecule designed to bind and inhibit WIPI2 activity, represents one promising approach. Piperlongumine has already been tested in lab animals and clinical trials are ongoing for its clinical implementation.

Senolytic drugs under development will likely target specific senescent cell types, including those linked to age-associated intervertebral disc degeneration such as p16INK4a-positive cells that release p16INK4a when exposed to light; similarly senescent glial cells have been implicated in Alzheimer’s disease while senescent thyrocytes may contribute to thyroid tumorigenesis.

Lifestyle Approaches

If you want to look younger, you probably already know that eating well, exercising regularly, getting enough restful sleep and minimizing stress are key components to combatting the aging process. They can help slow the pace of time-related diseases while simultaneously giving you more energy and optimism about life regardless of chronological age.

But what if the best way to reverse aging wasn’t cutting-edge biotechnology or expensive supplements? According to new research, simple lifestyle adjustments could actually rewind biological clock. Six women between 46 and 65 underwent an eight-week program which involved changes to diet, exercise, supplements and relaxation exercises and experienced reduced internal aging processes when tested again after 8 weeks.

Lifestyle changes include adopting a plant-based diet, eliminating processed food items from your diet, getting adequate sleep and managing stress effectively, exercising regularly and limiting fats such as canola oil, sunflower oil, safflower oil and margarine that contain unhealthy fats. Incorporating antioxidants like green tea, coffee or ginger into daily water routines may reduce risk factors associated with age-related diseases like heart disease, diabetes and cancer (Shanbhag 2021).

Not only can these changes help reverse biological aging, they can also improve mental health – helping you think more clearly, make healthier decisions and be an overall better person. Regular health screenings are also vital; for instance, colonoscopies can detect polyps that could potentially be removed through surgery, while vitamin C supplements provide essential antioxidant protection from oxidative damage that contributes to wrinkles and other signs of skin aging.


Many people rely on supplements for healthy aging and extended lives, yet most anti-ageing supplements do not deliver on their promise due to outdated science or being based upon surrogate biomarkers of aging such as inflammatory markers or mitochondrial function; focus on wrong cellular pathways; contain insufficient dosage; or have not been verified through animal or human studies.

Some supplements have shown some promise; GlyNAC is one such compound, known for improving mitochondrial functioning and epigenetics to extend mouse lifespan while providing some benefits in short-term trials with humans.

Nicotinamide Adenine Dinucleotide, or NR, is another promising supplement. This substance boosts levels of NAD coenzyme which assists with DNA repair and repairs damaged cell structures, improving brain and memory function while decreasing inflammation and increasing endurance (Dolopikou, 2020). Naturally found within our bodies as food such as nuts, beans and red meats; additionally it can be purchased as a dietary supplement.

Chemical compound PF4 has also been demonstrated to have positive anti-aging effects in mice. It reduces pro-aging immune system cells while increasing young immune system cells – leading to decreased inflammation responses, leading to more youthful appearance, improved cognition, and overall improved quality of life. You can find PF4 in some foods like salmon and green tea as well as being available as dietary supplements.

Future attempts at reversing aging could involve finding ways to induce pluripotency in cells so they can regenerate themselves and restore damaged organs, although this remains an ambitious long-term goal worth striving for. If successful regenerative medicine becomes a reality, this could pave the way to more effective disease treatment as well as whole-body rejuvenation – but until that day arrives all we can do is use approaches such as those presented here to live longer and healthier lives in the meantime.